Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2
Enveloped viruses are glycosylated, meaning that their envelope proteins are post-
translationally modified by the addition of glycans. Some glycosyltransferases that contribute …
translationally modified by the addition of glycans. Some glycosyltransferases that contribute …
Functional glycomics: Application to medical science and hepatology
Glycomics refers to the comprehensive analysis of glycans. Recent progress in
glycotechnology enables the determination of a variety of biological functions of glycans …
glycotechnology enables the determination of a variety of biological functions of glycans …
Chemoenzymatic Synthesis of a Rhamnose‐Functionalized Bispecific Nanobody as a Bispecific Antibody Mimic for Cancer Immunotherapy
H Hong, H Lin, D Li, L Gong, K Zhou, Y Li… - Angewandte …, 2022 - Wiley Online Library
Bispecific antibodies (BsAbs) are next‐generation therapeutics for complex cancer
treatment. Herein, we developed a dual‐targeting non‐IgG format of bsAbs by using a …
treatment. Herein, we developed a dual‐targeting non‐IgG format of bsAbs by using a …
One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody–Drug Conjugates through Site …
Antibody–drug conjugates (ADCs) are an important class of therapeutic agents that harness
the highly specific antigen targeting property of antibodies to deliver toxic drugs for targeted …
the highly specific antigen targeting property of antibodies to deliver toxic drugs for targeted …
Map** mechanisms in glycosylation reactions with donor reactivity: Avoiding generation of side products
CW Chang, MH Lin, CH Wu, TY Chiang… - The Journal of Organic …, 2020 - ACS Publications
The glycosylation reaction, which is key for the studies on glycoscience, is challenging due
to its complexity and intrinsic side reactions. Thioglycoside is one of the most widely used …
to its complexity and intrinsic side reactions. Thioglycoside is one of the most widely used …
Synthetic Antibody‐Rhamnose Cluster Conjugates Show Potent Complement‐Dependent Cell Killing by Recruiting Natural Antibodies
Monoclonal antibodies (mAbs) are one of the most rapidly growing drug classes used for the
treatment of cancer, infectious and autoimmune diseases. Complement‐dependent …
treatment of cancer, infectious and autoimmune diseases. Complement‐dependent …
Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for Leishmania major Infection
All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited
by yet uncharacterized glycotopes), which may play important roles in immunoglycomics:(a) …
by yet uncharacterized glycotopes), which may play important roles in immunoglycomics:(a) …
Statistical analysis of glycosylation reactions
CW Chang, MH Lin, CC Wang - Chemistry–A European …, 2021 - Wiley Online Library
Chemical synthesis is one of the practical approaches to access carbohydrate‐based
natural products and their derivatives with high quality and in a large quantity. However …
natural products and their derivatives with high quality and in a large quantity. However …
Modification of bacterial microcompartments with target biomolecules via post-translational SpyTagging
Bacterial microcompartments (BMCs) are proteinaceous organelle-like structures formed
within bacteria, often encapsulating enzymes and cellular processes, in particular, allowing …
within bacteria, often encapsulating enzymes and cellular processes, in particular, allowing …
Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients
L Zhong, L Gan, B Wang, T Wu, F Yao, W Gong… - Cell, 2025 - cell.com
Recently, oncolytic virus (OV) therapy has shown great promise in treating malignancies.
However, intravenous safety and inherent lack of immunity are two significant limitations in …
However, intravenous safety and inherent lack of immunity are two significant limitations in …