NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

Simple Summary Recent research has revealed the involvement of long non-coding RNAs
(lncRNAs) and micro RNAs (miRNAs) in glioma development and advancement, suggesting …

Multicomponent reactions have emerged as an important approach for the synthesis of
diverse and complicated chemical compounds. They have various advantages over two …

Neddylation, a type of protein post-translational modification that links the ubiquitin-like
protein NEDD8 to substrate proteins, can be involved in various significant cellular …

Glioblastoma (GBM) is the most aggressive and common malignant and CNS tumor,
accounting for 47.7% of total cases. Glioblastoma has an incidence rate of 3.21 cases per …

Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults,
characterized by extensive growth, a high recurrence rate, and resistance to treatment …

Recent multi-omics studies, including proteomics, transcriptomics, genomics, and
metabolomics have revealed the critical role of post-translational modifications (PTMs) in the …

Background Gliomas are the most common primary malignant tumours of the central
nervous system, and neddylation may be a potential target for the treatment of gliomas. Our …

IJMS | Free Full-Text | Advance in Targeted Cancer Therapy and Mechanisms of Resistance
Next Article in Journal Involvement of CONSTANS-like Proteins in Plant Flowering and Abiotic …

Background: One defining feature of various aggressive cancers, including glioblastoma
multiforme (GBM), is glycolysis upregulation, making its inhibition a promising therapeutic …