Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

The discovery of microRNAs (miRNAs) 20 years ago has advocated a new era of “small
molecular genetics.” About 2000 miRNAs are present that regulate one third of the genome …

MicroRNAs (miRNAs) are small and highly conserved noncoding RNAs that regulate gene
expression at the posttranscriptional level by binding to the 3′-UTR of target mRNAs …

The Hippo pathway, initially identified through screenings for mutant tumor suppressors in
Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by …

Prohibitin (PHB) was originally isolated and characterized as an anti-proliferative gene in rat
liver. The evolutionarily conserved PHB gene encodes two human protein isoforms with …

Melanoma is the utmost fatal kind of skin neoplasms. Molecular changes occurring during
the pathogenic processes of initiation and progression of melanoma are diverse and include …

Despite intensive treatment, 50% of children with high-risk neuroblastoma (HR-NB)
succumb to their disease. Progression through current trials evaluating the efficacy of new …

Management of advanced melanoma remains challenging, with most BRAF (B-Raf proto-
oncogene, serine/threonine kinase)-mutated metastatic patients relapsing within a few …

Prohibitin 1 is an evolutionary conserved and ubiquitously expressed protein that exerts
different biological functions depending on its subcellular localization. The role of prohibitin …

Rapid self-renewal of the intestinal epithelium requires the activity of intestinal stem cells
(ISCs) that are intermingled with Paneth cells (PCs) at the crypt base. PCs provide multiple …