In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …

Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …

Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However,
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …

The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably
in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond …

Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a
hallmark of most CNS disorders. The transformative potentials of recently approved gene …

RNA has sparked a revolution in modern medicine, with the potential to transform the way
we treat diseases. Recent regulatory approvals, hundreds of new clinical trials, the …

Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …

The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable
lipidoids containing extended alkyl branches have received tremendous attention, yet their …