Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …

Epigenetic phenomena play a central role in cell regulatory processes and are important
factors for understanding complex human disease. One of the best understood epigenetic …

Background and objective Maternal overnutrition has been implicated in affecting the
offspring by programming metabolic disorders such as obesity and diabetes, by …

Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …

TET proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further
oxidation products in DNA. The oxidized methylcytosines (oxi-mCs) facilitate DNA …

Exposure to environmental stressors, toxicants, and nutrient deficiencies can affect DNA in
several ways. Some exposures cause damage and alter the structure of DNA, but there is …

The epidemic of obesity has become pandemic, putting a significant burden on the world's
healthcare system. While the heritability of the disease is high, all the identified genetic …

Epigenetics plays a pivotal role in regulating gene expression and cellular differentiation.
DNA methylation, involving the addition of methyl groups to specific cytosine bases, is a well …

Recent genome-wide association studies corroborate classical research on developmental
programming indicating that obesity is primarily a neurodevelopmental disease strongly …