Non-genetic mechanisms have recently emerged as important drivers of anticancer drug
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …

Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3 hi GBM) show limited
benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying …

Abstract Background Circular RNAs (circRNAs) play important roles in the occurrence and
development of cancer and chemoresistance. DNA damage repair contributes to the …

Although metabolic reprogramming within tumor cells and tumor microenvironment (TME) is
well described in breast cancer, little is known about how the interplay of immune state and …

Malignant tumors have increased energy requirements due to growth, differentiation or
response to stress. A significant number of studies in recent years have described …

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …

In this study, a novel selenium@ zeolitic imidazolate framework core/shell nanocomposite
stabilised with alginate was used to improve the anti-tumour activity of curcumin. The …

Drug discovery and development (DDD) is a highly complex process that necessitates
precise monitoring and extensive data analysis at each stage. Furthermore, the DDD …

Genomic instability is a common hallmark of human tumours. As a carrier of genetic
information, DNA is constantly threatened by various damaging factors that, if not repaired in …