Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

E Blass, PA Ott - Nature reviews Clinical oncology, 2021 - nature.com
Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer

L Huang, Y Rong, X Tang, K Yi, P Qi, J Hou, W Liu… - Molecular cancer, 2022 - Springer
Abstract Background Dendritic cells (DCs) are central for the initiation and regulation of
innate and adaptive immunity in the tumor microenvironment. As such, many kinds of DC …

Harnessing innate immune pathways for therapeutic advancement in cancer

A Hu, L Sun, H Lin, Y Liao, H Yang… - Signal Transduction and …, 2024 - nature.com
The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Augmenting immunotherapy via bioinspired MOF‐based ROS homeostasis disruptor with nanozyme‐cascade reaction

R Wang, M Qiu, L Zhang, M Sui, L **ao, Q Yu… - Advanced …, 2023 - Wiley Online Library
Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy
remains limited by the insufficient immune response in the “cold” tumor. Nanozyme‐based …

Myeloid cell-targeted therapies for solid tumours

S Goswami, S Anandhan, D Raychaudhuri… - Nature Reviews …, 2023 - nature.com
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Biomimetic and bioinspired nano‐platforms for cancer vaccine development

C Feng, P Tan, G Nie, M Zhu - Exploration, 2023 - Wiley Online Library
The advent of immunotherapy has revolutionized the treating modalities of cancer. Cancer
vaccine, aiming to harness the host immune system to induce a tumor‐specific killing effect …

Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy

Y Zhang, X Hou, S Du, Y Xue, J Yan, DD Kang… - Nature …, 2023 - nature.com
Effective cancer immunotherapy is usually blocked by immunosuppressive factors in the
tumour microenvironment, resulting in tumour promotion, metastasis and recurrence. Here …

Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis

Y Ren, R Wang, S Weng, H Xu, Y Zhang, S Chen… - Molecular cancer, 2023 - Springer
The reversible oxidation-reduction homeostasis mechanism functions as a specific signal
transduction system, eliciting related physiological responses. Disruptions to redox …

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

RS Laureano, J Sprooten, I Vanmeerbeerk… - …, 2022 - Taylor & Francis
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …