Conspectus DNA G-quadruplex secondary structures formed in guanine-rich human
telomeres and oncogene promoters are functionally important and have emerged as a …

The G-quadruplex structure is crucial in several biological processes, including DNA
replication, transcription, and genomic maintenance. G-quadruplex-based fluorescent …

Abstract G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich
sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming …

G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four
guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal …

Human telomeres can form DNA G‐quadruplex (G4), an attractive target for anticancer
drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for …

Abstract G‐quadruplexes (G4s) are peculiar DNA or RNA tertiary structures that are involved
in the regulation of many biological events within mammalian cells, bacteria, and viruses …

LSD1 was significantly over-expressed in several cancer types, and its aberrant
overexpression was revealed to play a crucial role in the initiation and progression of …

The G-quadruplexes (G4s) formed in the PDGFR-β gene promoter are transcriptional
modulators and amenable to small-molecule targeting. Berberine (BER), a clinically …

G-quadruplexes turned out to be important targets for the development of novel targeted
anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have …

Natural protoberberine alkaloids were first identified and characterized as potent, selective
and cellular active lysine specific demethylase 1 (LSD1) inhibitors. Due to our study …