Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-
molecule compounds starting from fragments binding weakly to targets. As FBDD exhibits …

The emergence of drug-resistant mycobacteria, including Mycobacterium tuberculosis (Mtb)
and non-tuberculous mycobacteria (NTM), poses an increasing global threat that urgently …

In this study, 13 new hybrid compounds were synthesized starting from the natural product
oleanolic acid and their in vitro cytotoxic activities were investigated on the BEAS-2B and …

Pyruvate kinase M2 (PKM2) catalyzes the conversion of phosphoenolpyruvate (PEP) to
pyruvate. It plays a central role in the metabolic reprogramming of cancer cells and is …

Introduction: The development of drug candidates with a defined selectivity profile and a
unique molecular structure is of fundamental interest for drug discovery. In contrast to the …

An efficient methodology has been developed for the synthesis of tetra-and pentasubstituted
pyrroles via oxidative self-dimerization of N-propargylamines catalyzed by silver benzoate in …

A recent editorial (Aldrich et al. The Ecstasy and Agony of Assay Interference Compounds. J.
Chem. Inf. Model. 2017, 57, 387–390) is examined critically. When assessing assay hits …

Fragment‐based screening has become indispensable in drug discovery. Yet, the weak
binding affinities of these small molecules still represent a challenge for the reliable …

Discovery of new drug binding sites on well-established targets is of great interest as it
facilitates the design of new mechanistic inhibitors to overcome the acquired drug …

The participation of organic fluorine as a halogen bond donor is rare and is sensitive to the
electronic environment in the vicinity of the fluorine atom. The enhancement in the …