Chromatin accessibility profiling by ATAC-seq
The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …
simple and scalable way to detect the unique chromatin landscape associated with a cell …
Pathway paradigms revealed from the genetics of inflammatory bowel disease
DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …
amplified by the confluence of multiple genetic and environmental variables that perturb the …
Systematic differences in discovery of genetic effects on gene expression and complex traits
Most signals in genome-wide association studies (GWAS) of complex traits implicate
noncoding genetic variants with putative gene regulatory effects. However, currently …
noncoding genetic variants with putative gene regulatory effects. However, currently …
Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge
of circulating immune cell types and states associated with SLE remains incomplete. We …
of circulating immune cell types and states associated with SLE remains incomplete. We …
Clonal replacement of tumor-specific T cells following PD-1 blockade
Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the
clinical care of patients with cancer. However, whether the T cell response to checkpoint …
clinical care of patients with cancer. However, whether the T cell response to checkpoint …
[HTML][HTML] ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis
The advent of single-cell chromatin accessibility profiling has accelerated the ability to map
gene regulatory landscapes but has outpaced the development of scalable software to …
gene regulatory landscapes but has outpaced the development of scalable software to …
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
RNA-Seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types
The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …
strategies to understand and treat diseases. We characterized 29 immune cell types within …
Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases
Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …
associated with complex traits. These associations could reveal the molecular mechanisms …