Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …

Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

Highly selective gene expression is a key requirement for antigenic variation in several
pathogens, allowing evasion of host immune responses and maintenance of persistent …

Variant surface glycoprotein (VSG) coats bloodstream form Trypanosoma brucei parasites,
and monoallelic VSG expression underpins the antigenic variation necessary for …

Abstract A Variant Surface Glycoprotein (VSG) coat protects bloodstream form Trypanosoma
brucei. Prodigious amounts of VSG mRNA (~ 7-10% total) are generated from a single RNA …

For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the
most deleterious types of DNA lesions. DSB processing and repair can cause sequence …

Human African trypanosomiasis, or slee** sickness, results from infection by two
subspecies of the protozoan flagellate parasite Trypanosoma brucei, termed Trypanosoma …

Abstract The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which
relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian …

The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream
and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat …

African trypanosomes are early divergent protozoan parasites responsible for high mortality
and morbidity as well as a great economic burden among the world's poorest populations …