Looking beyond COVID-19 vaccine phase 3 trials

JH Kim, F Marks, JD Clemens - Nature medicine, 2021 - nature.com
After the recent announcement of COVID-19 vaccine efficacy in clinical trials by several
manufacturers for protection against severe disease, a comprehensive post-efficacy strategy …

Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

[HTML][HTML] What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

SH Hodgson, K Mansatta, G Mallett, V Harris… - The lancet infectious …, 2021 - thelancet.com
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …

The use of viral vectors in vaccine development

T Travieso, J Li, S Mahesh, JDFRE Mello, M Blasi - npj Vaccines, 2022 - nature.com
Vaccines represent the single most cost-efficient and equitable way to combat and eradicate
infectious diseases. While traditional licensed vaccines consist of either …

Next-generation vaccine platforms for COVID-19

D van Riel, E de Wit - Nature materials, 2020 - nature.com
Consensus among experts is that only an effective COVID-19 vaccine will end the
pandemic. This Comment focuses on how this pandemic has accelerated the development …

Vaccines for COVID-19

JS Tregoning, ES Brown… - Clinical & …, 2020 - academic.oup.com
Since the emergence of COVID-19, caused by the SARS-CoV-2 virus at the end of 2019,
there has been an explosion of vaccine development. By 24 September 2020, a staggering …

Ebola virus disease

ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

The long road toward COVID-19 herd immunity: vaccine platform technologies and mass immunization strategies

LSF Frederiksen, Y Zhang, C Foged… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for effective countermeasures against the current emergence and
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …

Develo** therapeutic approaches for twenty-first-century emerging infectious viral diseases

RM Meganck, RS Baric - Nature medicine, 2021 - nature.com
The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Public health emergencies of international concern: a historic overview

A Wilder-Smith, S Osman - Journal of travel medicine, 2020 - academic.oup.com
Abstract Rationale The International Health Regulations (IHR) have been the governing
framework for global health security since 2007. Declaring public health emergencies of …