Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Mitochondrially derived peptides represent a new class of circulating signalling molecules.
Humanin, the first member of this class, has been shown to have several metabolic effects …

A ketogenic diet (KD; high-fat, low-carbohydrate) can benefit refractory epilepsy, but
underlying mechanisms are unknown. We used mice inducibly expressing a mutated form of …

Impaired or deficient autophagy is believed to cause or contribute to aging, as well as a
number of age-related pathologies. The exact mechanism through which alterations in …

Abstract Type 2 diabetes (T2D) is strongly linked to obesity and an adipose tissue
unresponsive to insulin. The insulin resistance is due to defective insulin signaling, but …

Cardiovascular disease is common in patients with diabetes and is a significant contributor
to the high mortality rates associated with diabetes. Heart failure is common in diabetic …

Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Background A systematic assessment of potential disease-modifying compounds for
Parkinson's disease concluded that pioglitazone could hold promise for the treatment of …

Neurodegenerative diseases are debilitating nervous system disorders attributed to various
conditions such as body aging, gene mutations, genetic factors, and immune system …