Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Extended wakefulness is associated with reduced performance and the build-up of sleep
pressure. In the cortex, this manifests as changes in network activity. These changes show …

Reversible silencing of neuronal activity is a powerful approach for isolating the roles of
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …

Abstract Information transfer within neuronal circuits depends on the balance and recurrent
activity of excitatory and inhibitory neurotransmission. Chloride (Cl−) is the major central …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic
inhibition during and beyond brain development. This regulation is mainly dependent on the …

Secondary generalized seizure (sGS) is a major source of disability in temporal lobe
epilepsy (TLE) with unclear cellular/circuit mechanisms. Here we found that clinical TLE …

We developed a neural network model that can account for major elements common to
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …