One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …

Reactive oxygen species (ROS) are created in cells during oxidative phosphorylation by the
respiratory chain in the mitochondria or by the family of NADPH oxidase (NOX) complexes …

Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …

Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …

The failure in effective cancer treatment is thought to be attributed to a subpopulation of
tumor cells with stem cell-like properties. These cancer stem cells (CSCs) are intimately …

Reactive oxygen species (ROS) have been extensively studied in the induction of
inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS …

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Despite
intense investigation, no neuroprotective agents for TBI have yet translated to the clinic …

Systemic lupus erythematosus (SLE) and its renal manifestation Lupus nephritis (LN) are
characterized by a dysregulated immune system, autoantibodies, and injury to the renal …

Evidence demonstrated that metabolic-associated T cell abnormalities could be detected in
the early stage of RA development. In this context, molecular evaluations have revealed …

Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen
species (ROS) that destabilize the homeostatic redox balance. High levels of ROS can …