Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products

K Yeshi, R Ruscher, L Hunter, NL Daly… - Journal of clinical …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic and life-long disease characterized by
gastrointestinal tract inflammation. It is caused by the interplay of the host's genetic …

Raging the war against inflammation with natural products

A Attiq, J Jalil, K Husain, W Ahmad - Frontiers in pharmacology, 2018 - frontiersin.org
Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of
choice for treating numerous inflammatory diseases including rheumatoid arthritis. The …

In vitro anti-inflammatory activity of spherical silver nanoparticles and monodisperse hexagonal gold nanoparticles by fruit extract of Prunus serrulata: a green …

P Singh, S Ahn, JP Kang, S Veronika… - Artificial cells …, 2018 - Taylor & Francis
Recently, green metal nanoparticles have received global attention owing to their
economical synthesis, biocompatible nature, widespread biomedical and environmental …

An oriental medicine, Hyungbangpaedok-San attenuates motor paralysis in an experimental model of multiple sclerosis by regulating the T cell response

JH Choi, MJ Lee, M Jang, EJ Kim, I Shim, HJ Kim… - PloS one, 2015 - journals.plos.org
The preventive and therapeutic mechanisms in multiple sclerosis are not clearly understood.
We investigated whether Hyungbangpaedok-san (HBPDS), a traditional herbal medicine …

Anti-inflammatory properties of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression

RJ Choi, TM Ngoc, KH Bae, HJ Cho, DD Kim… - European Journal of …, 2013 - Elsevier
There is a growing interest in natural products that potentially have anti-inflammatory
properties and inhibit P-glycoprotein (P-gp) function. In this report, we assessed the effects …

Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP …

SS Mizokami, NS Arakawa, SR Ambrosio… - Journal of Natural …, 2012 - ACS Publications
Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants
including Sphagneticola trilobata. The only documented evidence for its antinociceptive …

[HTML][HTML] Anti-Inflammatory and Anticancer Effects of Kaurenoic Acid in Overcoming Radioresistance in Breast Cancer Radiotherapy

TW Kim, SG Ko - Nutrients, 2024 - mdpi.com
Background/Objectives: Peroxisome proliferator–activated receptor γ (PPARγ) plays a key
role in mediating anti-inflammatory and anticancer effects in the tumor microenvironment …

Kaurenoic acid nanocarriers regulates cytokine production and inhibit breast cancer cell migration

KCB Ferreira, ABC dos Santos Valle… - Journal of Controlled …, 2022 - Elsevier
Breast cancer is the type of cancer with the highest incidence in women around the world.
Noteworthy, the triple-negative subtype affects 20% of the patients while presenting the …

Traditional uses, phytochemistry, pharmacology, toxicity and quality control of medicinal genus Aralia: A review

Y Xu, J Liu, Y Zeng, S **, W Liu, Z Li, X Qin… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Aralia, which belongs to Araliaceae family, is mainly
distributed in Asia, such as China, Japan and South Korea. It has a long medicinal history …

Insight into the molecular mechanism of a herbal injection by integrating network pharmacology and in vitro

Y Ma, X Zhang, Z Su, N Li, L Cao, G Ding… - Journal of …, 2015 - Elsevier
Chinese medical herbs could treat complex diseases through the synergistic effect of multi-
components, multi-targets and multi-channels. However, it was difficult to systematically …