Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are sha** how we study and target Tauopathies
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Tau proteolysis in the pathogenesis of tauopathies: neurotoxic fragments and novel biomarkers
JP Quinn, NJ Corbett, KAB Kellett… - Journal of Alzheimer's …, 2018 - content.iospress.com
With predictions showing that 131.5 million people worldwide will be living with dementia by
2050, an understanding of the molecular mechanisms underpinning disease is crucial in the …
2050, an understanding of the molecular mechanisms underpinning disease is crucial in the …
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ …
In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
Posttranslational modifications mediate the structural diversity of tauopathy strains
Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies.
However, it is not known what controls the formation and templated seeding of strain-specific …
However, it is not known what controls the formation and templated seeding of strain-specific …
Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation
Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative
tauopathies such as Alzheimer's disease. A central unanswered question is why tau …
tauopathies such as Alzheimer's disease. A central unanswered question is why tau …
Head‐to‐head comparison of clinical performance of CSF phospho‐tau T181 and T217 biomarkers for Alzheimer's disease diagnosis
TK Karikari, A Emeršič, A Vrillon… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Phosphorylated tau (p‐tau) in cerebrospinal fluid (CSF) is an established
Alzheimer's disease (AD) biomarker. Novel immunoassays targeting N‐terminal and mid …
Alzheimer's disease (AD) biomarker. Novel immunoassays targeting N‐terminal and mid …
Secretion of tau via an unconventional non-vesicular mechanism
M Merezhko, CA Brunello, X Yan, H Vihinen, E Jokitalo… - Cell reports, 2018 - cell.com
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …
appear to spread throughout the brain via a cell-to-cell transmission process that includes …
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological
features of many neurodegenerative diseases. They consist largely of aggregated forms of …
features of many neurodegenerative diseases. They consist largely of aggregated forms of …
Microglia in Alzheimer's disease in the context of tau pathology
JR Perea, M Bolós, J Avila - Biomolecules, 2020 - mdpi.com
Microglia are the cells that comprise the innate immune system in the brain. First described
more than a century ago, these cells were initially assigned a secondary role in the central …
more than a century ago, these cells were initially assigned a secondary role in the central …
The anesthetic sevoflurane induces tau trafficking from neurons to microglia
Accumulation and spread of tau in Alzheimer's disease and other tauopathies occur in a
prion-like manner. However, the mechanisms and downstream consequences of tau …
prion-like manner. However, the mechanisms and downstream consequences of tau …