Structural biology of the tumor suppressor p53
The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …
Master regulatory role of p63 in epidermal development and disease
E Soares, H Zhou - Cellular and Molecular Life Sciences, 2018 - Springer
The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …
Structural diversity of p63 and p73 isoforms
C Osterburg, V Dötsch - Cell death & differentiation, 2022 - nature.com
The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …
structure determination have revealed a high similarity of crucial domains between p53, p63 …
p53 contains large unstructured regions in its native state
S Bell, C Klein, L Müller, S Hansen… - Journal of molecular …, 2002 - Elsevier
The human tumor suppressor protein p53 is understood only to some extent on a structural
level. We performed a comprehensive biochemical and biophysical structure–function …
level. We performed a comprehensive biochemical and biophysical structure–function …
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
The induction of apoptosis by p53 in response to cellular stress is its most conserved
function and crucial for p53 tumor suppression. We recently reported that p53 directly …
function and crucial for p53 tumor suppression. We recently reported that p53 directly …
Fibrillar aggregates of the tumor suppressor p53 core domain
D Ishimaru, LR Andrade, LSP Teixeira… - Biochemistry, 2003 - ACS Publications
Alzheimer's disease, Parkinson's disease, cystic fibrosis, prion diseases, and many types of
cancer are considered to be protein conformation diseases. Most of them are also known as …
cancer are considered to be protein conformation diseases. Most of them are also known as …
Differential recognition of response elements determines target gene specificity Forp53 and P63
M Osada, HL Park, Y Nagakawa… - … and cellular biology, 2005 - Am Soc Microbiol
Abstract p63 is a member of the p53 tumor suppressor gene family, which regulates
downstream target gene expression by binding to sequence-specific response elements …
downstream target gene expression by binding to sequence-specific response elements …
Structure of the p53 Core Domain Dimer Bound to DNA*♦
The p53 tumor suppressor protein binds to DNA as a dimer of dimers to regulate
transcription of genes that mediate responses to cellular stress. We have prepared a cross …
transcription of genes that mediate responses to cellular stress. We have prepared a cross …
ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
KE King, RM Ponnamperuma, T Yamashita, T Tokino… - Oncogene, 2003 - nature.com
ΔNp63 is overexpressed in squamous carcinomas where it is associated with proliferation
and is believed to enhance cell growth by blocking p53-mediated transactivation. In normal …
and is believed to enhance cell growth by blocking p53-mediated transactivation. In normal …
The functional domains in p53 family proteins exhibit both common and distinct properties.
KL Harms, X Chen - Cell Death & Differentiation, 2006 - search.ebscohost.com
The article focuses on a study that examines the functional domains in p53 family proteins.
The recent study shows that p53 family proteins are comprised of several functional domains …
The recent study shows that p53 family proteins are comprised of several functional domains …