ROS: Basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022‏ - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors

JL Silveira Rossi, SM Barbalho… - Diabetes/metabolism …, 2022‏ - Wiley Online Library
Metabolic syndrome (MS) is a chronic non‐infective syndrome characterised clinically by a
set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity …

[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological reviews, 2023‏ - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Ketogenic diet induces p53-dependent cellular senescence in multiple organs

SJ Wei, JR Schell, ES Chocron, M Varmazyad, G Xu… - Science …, 2024‏ - science.org
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of
ketones. While KDs improve certain health conditions and are popular for weight loss …

PGC‐1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

S Rius-Pérez, I Torres-Cuevas, I Millán… - Oxidative medicine …, 2020‏ - Wiley Online Library
Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Skeletal muscle: A review of molecular structure and function, in health and disease

K Mukund, S Subramaniam - Wiley Interdisciplinary Reviews …, 2020‏ - Wiley Online Library
Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

[HTML][HTML] The role of oxidative stress in skeletal muscle myogenesis and muscle disease

D Lian, MM Chen, H Wu, S Deng, X Hu - Antioxidants, 2022‏ - mdpi.com
The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle
cause it to continuously produce moderate levels of oxidant species, such as reactive …

Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production

H Wu, J Guo, Y Yao, S Xu - Fish & Shellfish Immunology, 2022‏ - Elsevier
Nanoplastics (NPs) existing in aquatic ecosystem is an emerging environmental pollutant,
which has become a nagging serious environmental problem. Miniaturized plastic fragments …

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

M Lacroix, R Riscal, G Arena, LK Linares… - Molecular metabolism, 2020‏ - Elsevier
Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Vanadium in biological action: chemical, pharmacological aspects, and metabolic implications in diabetes mellitus

S Treviño, A Díaz, E Sánchez-Lara… - Biological trace element …, 2019‏ - Springer
Vanadium compounds have been primarily investigated as potential therapeutic agents for
the treatment of various major health issues, including cancer, atherosclerosis, and …