Genomic analyses have revealed mutational footprints associated with DNA maintenance
gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA …

There are many possible failure points in the transmission of genetic information that can
produce heritable germline mutations. Once a mutation has been passed from parents to …

Recent reports have identified differences in the mutational spectra across human
populations. Although some of these reports have been replicated in other cohorts, most …

Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …

Although evolutionary biologists have long theorized that variation in DNA repair efficacy
might explain some of the diversity of lifespan and cancer incidence across species, we …

Two competing proposals about the degree to which selection affects codon usage of
angiosperm chloroplast genes are examined. The first, based on observations that codon …

Recent studies have suggested that the human germline mutation rate and spectrum evolve
rapidly. Variation in generation time has been linked to these changes, though its …

Germline mutation is the mechanism by which genetic variation in a population is created.
Inferences derived from mutation rate models are fundamental to many population genetics …

Mutation rates and spectra differ among human populations. Here, we examine whether this
variation could be explained by evolution at mutation modifiers. To this end, we consider …

Non-African humans appear to carry a few per cent archaic DNA due to ancient inter-
breeding. This modest legacy and its likely recent timing imply that most introgressed …