Perspective on the Martini model
The Martini model, a coarse-grained force field for biomolecular simulations, has found a
broad range of applications since its release a decade ago. Based on a building block …
broad range of applications since its release a decade ago. Based on a building block …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
The multifaceted role of SNARE proteins in membrane fusion
Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …
biological processes including viral infection, cell fertilization, as well as intracellular …
The function of VAMP2 in mediating membrane fusion: An overview
C Yan, J Jiang, Y Yang, X Geng… - Frontiers in Molecular …, 2022 - frontiersin.org
Vesicle-associated membrane protein 2 (VAMP2, also known as synaptobrevin-2), encoded
by VAMP2 in humans, is a key component of the soluble N-ethylmaleimide-sensitive factor …
by VAMP2 in humans, is a key component of the soluble N-ethylmaleimide-sensitive factor …
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are
still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and …
still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and …
The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain
The genome of Weissella oryzae SG25T was recently sequenced and a botulinum
neurotoxin (BoNT) like gene was identified by bioinformatics methods. The typical three …
neurotoxin (BoNT) like gene was identified by bioinformatics methods. The typical three …
Interplay between membrane curvature and cholesterol: Role of palmitoylated caveolin-1
Abstract Caveolin-1 (cav-1) is an important player in cell signaling and endocytosis that has
been shown to colocalize with cholesterol-rich membrane domains. Experimental studies …
been shown to colocalize with cholesterol-rich membrane domains. Experimental studies …
Expansion of the fusion stalk and its implication for biological membrane fusion
HJ Risselada, G Bubnis… - Proceedings of the …, 2014 - National Acad Sciences
Over the past 20 years, it has been widely accepted that membrane fusion proceeds via a
hemifusion step before opening of the productive fusion pore. An initial hourglass-shaped …
hemifusion step before opening of the productive fusion pore. An initial hourglass-shaped …
Molecular mechanism of fusion pore formation driven by the neuronal SNARE complex
S Sharma, M Lindau - … of the National Academy of Sciences, 2018 - National Acad Sciences
Release of neurotransmitters from synaptic vesicles begins with a narrow fusion pore, the
structure of which remains unresolved. To obtain a structural model of the fusion pore, we …
structure of which remains unresolved. To obtain a structural model of the fusion pore, we …
Fusion pores and their control of neurotransmitter and hormone release
Ca2+-triggered exocytosis functions broadly in the secretion of chemical signals, enabling
neurons to release neurotransmitters and endocrine cells to release hormones. The …
neurons to release neurotransmitters and endocrine cells to release hormones. The …