Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Although the shapes of organisms are encoded in their genome, the developmental
processes that lead to the final form of vertebrates involve a constant feedback between …

Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at
the cell membrane that transduce adhesion-dependent signals to control a multitude of …

The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

E-cadherin is a single-pass transmembrane protein that mediates homophilic cell–cell
interactions. Tumour progression is often associated with the loss of E-cadherin function and …