The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Magnetic nanoparticles in general, and iron oxide nanoparticles in particular, have been
studied extensively during the past 20 years for numerous biomedical applications. The …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

The Coronavirus disease 2019 (COVID)-19 pandemic has already affected millions
worldwide, with a current mortality rate of 2.2%. While it is well-established that severe acute …

Although recent technical advances in thrombectomy have revolutionised acute stroke
treatment, prevalence of disability and death related to stroke remain high. Therefore …

Background: Platelet cross-linking during arterial thrombosis involves von Willebrand Factor
(VWF) multimers. Therefore, proteolysis of VWF appears promising to disaggregate platelet …

Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant
advancement in treating neurological diseases. The BBB is a tightly packed layer of …

Trauma is responsible for 1 in 10 deaths worldwide and is the leading cause of death of
people less than 45 years old. 1 The two most common causes of death in trauma victims …

Despite decades of promising preclinical validation and clinical translation, ischemic stroke
still remains as one of the leading causes of death and disability worldwide. Within its …