After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral
immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages …

Stroke pathology and its treatments conventionally focus on the brain. Probing inflammation,
a critical secondary cell death mechanism in stroke, has been largely relegated to the brain …

Ischemic stroke is the leading cause of immortal disability and death worldwide. For
treatment in the acute phase, it is necessary to control excessive reactive oxygen species …

Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic
options. However, accumulating evidence indicates a central role of inflammation in all …

The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …

Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and
impede post-stroke brain recovery. CD4+ CD25+ Foxp3+ regulatory T (Treg) cells play …

Cerebral small vessel disease (CSVD) is the most common chronic vascular disease
involving the whole brain. Great progress has been made in clinical imaging, pathological …

Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are
well-established. However, more recent studies have uncovered compelling beneficial roles …

Background & aims Numerous references made clear that Triphala is revered as a multiuse
therapeutic and perhaps even panacea historically. Nevertheless, the protective mechanism …

Increasing evidence hints to the central role of neuroinflammation in the development of post-
stroke depression. Danger signals released in the acute phase of ischemia trigger microglial …