Optimal management of elderly patients with glioblastoma

N Laperriere, M Weller, R Stupp, JR Perry… - Cancer treatment …, 2013 - Elsevier
Median age at diagnosis in patients with glioblastoma (GB) is slowly increasing with an
aging population in Western countries, and was 64years in 2006. The number of patients …

Oncolytic viral therapy for gliomas: advances in the mechanisms and approaches to delivery

A Romanishin, A Vasilev, E Khasanshin, A Evtekhov… - Virology, 2024 - Elsevier
Glioma is a diverse category of tumors originating from glial cells encompasses various
subtypes, based on the specific type of glial cells involved. The most aggressive is …

Neural stem cell–mediated enzyme/prodrug therapy for glioma: Preclinical studies

KS Aboody, J Najbauer, MZ Metz, M D'Apuzzo… - Science translational …, 2013 - science.org
High-grade gliomas are extremely difficult to treat because they are invasive and therefore
not curable by surgical resection; the toxicity of current chemo-and radiation therapies limits …

Quantitating interfraction target dynamics during concurrent chemoradiation for glioblastoma: a prospective serial imaging study

J Stewart, A Sahgal, Y Lee, H Soliman… - International Journal of …, 2021 - Elsevier
Purpose Magnetic resonance image (MRI) guided radiation therapy has the potential to
improve outcomes for glioblastoma by adapting to tumor changes during radiation therapy …

Management of glioblastoma multiforme in a patient treated with ketogenic metabolic therapy and modified standard of care: a 24-month follow-up

AMA Elsakka, MA Bary, E Abdelzaher… - Frontiers in …, 2018 - frontiersin.org
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in
more than 40 years. Here, we report the case of a 38-year-old man who presented with …

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis

E Rogozińska, A Kernohan, S Jefferies… - Cochrane Database …, 2020 - cochranelibrary.com
Background A glioblastoma is a fatal type of brain tumour for which the standard of care is
maximum surgical resection followed by chemoradiotherapy, when possible. Age is an …

Provocative question: should ketogenic metabolic therapy become the standard of care for glioblastoma?

TN Seyfried, L Shelton, G Arismendi-Morillo… - Neurochemical …, 2019 - Springer
No major advances have been made in improving overall survival for glioblastoma (GBM) in
almost 100 years. The current standard of care (SOC) for GBM involves immediate surgical …

[HTML][HTML] Temperature and pH-responsive in situ hydrogels of gelatin derivatives to prevent the reoccurrence of brain tumor

JH Kang, MH Turabee, DS Lee, YJ Kwon… - Biomedicine & …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a grade IV malignant brain tumor with a median survival
time of approximately 12–16 months. Because of its highly aggressive and heterogeneous …

Metabolic management of microenvironment acidity in glioblastoma

TN Seyfried, G Arismendi-Morillo, G Zuccoli… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma (GBM), similar to most cancers, is dependent on fermentation metabolism for
the synthesis of biomass and energy (ATP) regardless of the cellular or genetic …

Temozolomide and other potential agents for the treatment of glioblastoma multiforme

DT Nagasawa, F Chow, A Yew, W Kim… - Neurosurgery clinics of …, 2012 - Elsevier
This article provides historical and recent perspectives related to the use of temozolomide
for the treatment of glioblastoma multiforme. Temozolomide has quickly become part of the …