The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X **e… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

J Li, K Kataoka - Journal of the American Chemical Society, 2020 - ACS Publications
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …

A neutrophil mimicking metal-porphyrin-based nanodevice loaded with porcine pancreatic elastase for cancer therapy

T Cui, Y Zhang, G Qin, Y Wei, J Yang, Y Huang… - Nature …, 2023 - nature.com
Precise discrimination and eradication of cancer cells by immune cells independent of
antigen recognition is promising for solid tumor therapeutics, yet remains a tremendous …

DNA nanostructure-based nucleic acid probes: construction and biological applications

DX Wang, J Wang, YX Wang, YC Du, Y Huang… - Chemical …, 2021 - pubs.rsc.org
In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …

DNA nanostructures for exploring cell–cell communication

Y Wang, Y **ong, K Shi, CY Effah, L Song… - Chemical Society …, 2024 - pubs.rsc.org
The process of coordinating between the same or multiple types of cells to jointly execute
various instructions in a controlled and carefully regulated environment is a very appealing …

Harnessing engineered immune cells and bacteria as drug carriers for cancer immunotherapy

J Jiang, Y Huang, Z Zeng, C Zhao - ACS nano, 2023 - ACS Publications
Immunotherapy continues to be in the spotlight of oncology therapy research in the past few
years and has been proven to be a promising option to modulate one's innate and adaptive …

Aptamer-Based Nongenetic Reprogramming of CARs Enables Flexible Modulation of T Cell-Mediated Tumor Immunotherapy

Q Zhang, L Wu, Y Zhang, D Wang, Y Sima… - ACS Central …, 2024 - ACS Publications
Innovating the design of chimeric antigen receptors (CARs) beyond conventional structures
would be necessary to address the challenges of efficacy, safety, and applicability in T cell …

Fluid nanoporous microinterface enables multiscale-enhanced affinity interaction for tumor-derived extracellular vesicle detection

Q Niu, J Gao, K Zhao, X Chen, X Lin, C Huang… - Proceedings of the …, 2022 - pnas.org
Tumor-derived extracellular vesicles (T-EVs) represent valuable markers for tumor diagnosis
and treatment guidance. However, nanoscale sizes and the low abundance of marker …

Cell surface-localized imaging and sensing

HR Jia, YX Zhu, QY Duan, FG Wu - Chemical Society Reviews, 2021 - pubs.rsc.org
Systematically dissecting the molecular basis of the cell surface as well as its related
biological activities is considered as one of the most cutting-edge fields in fundamental …

New opportunities for immunomodulation of the tumour microenvironment using chemical tools

JY Su, WH Li, YM Li - Chemical Society Reviews, 2022 - pubs.rsc.org
Immunotherapy is recognised as an attractive method for the treatment of cancer, and
numerous treatment strategies have emerged over recent years. Investigations of the tumour …