Automation and miniaturization are key issues of high-throughput research projects in the
post-genomic era. The implementation of robotics and parallelization has enabled …

For the successful X-ray structure determination of macromolecules, it is first necessary to
identify, usually by matrix screening, conditions that yield some sort of crystals. Initial crystals …

Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular
Crystallography describes the fundamentals, practices, and applications of protein …

This paper reports a composite microfluidic system for performing protein crystallization trials
in nanoliter aqueous droplets inside capillaries suitable for X-ray diffraction and the …

Structural genomics is emerging as a principal approach to define protein structure–function
relationships. To apply this approach on a genomic scale, novel methods and technologies …

Crystallization trials at the Division of Structural Biology in Oxford are now almost exclusively
carried out using a high-throughput workflow implemented in the Oxford Protein Production …

High throughput screening of crystallization of a target material is accomplishcd by
simultancously introducing a solution of the target material into a plurality of chambers of a …

The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe
acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength …

This paper introduces nucleation theory applied to crystallizing protein solutions. It is shown
that the classical approach explains the available nucleation data under most conditions …

(60) Provisional application No. 60/558.316, filed on Mar. mal control source. Reagents for
carrying out a desired reac 30, 2004, provisional application No. 60/557,715, tion are …