METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner

X Pan, X Hong, S Li, P Meng, F **ao - Experimental & molecular …, 2021 - nature.com
Breast cancer (BC) is the most prevalent malignant neoplasm among women and is the fifth
most common cause of cancer-associated death worldwide. Acquired chemoresistance …

The role of microRNAs on doxorubicin drug resistance in breast cancer

K Jamialahmadi, F Zahedipour… - Journal of Pharmacy and …, 2021 - academic.oup.com
Objectives Resistance to chemotherapeutic drugs is a serious challenge for effective therapy
of cancers. Doxorubicin is a drug which is typically used for breast cancer treatment. Several …

Levels of microRNA heterogeneity in cancer biology

N Petrovic, S Ergün, ER Isenovic - Molecular diagnosis & therapy, 2017 - Springer
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression, involved in the
silencing of messenger RNA (mRNA) translation. The importance of miRNA signatures in …

The lncRNA-GAS5/miR-221-3p/DKK2 axis modulates ABCB1-mediated adriamycin resistance of breast cancer via the Wnt/β-catenin signaling pathway

Z Chen, T Pan, D Jiang, L **, Y Geng, X Feng… - … Therapy-Nucleic Acids, 2020 - cell.com
Drug resistance, including adriamycin (ADR)-based therapeutic resistance, is a crucial
cause of chemotherapy failure in breast cancer treatment. Acquired chemoresistance has …

Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction

E Coskunpinar, HA Cakmak, AK Kalkan… - Gene, 2016 - Elsevier
Recent studies have reported circulating microRNAs (miRNAs) as novel biomarkers for
cardiovascular diseases including acute myocardial infarction, heart failure, diabetes …

[HTML][HTML] Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion

W Qin, Y Tang, N Yang, X Wei, J Wu - Fertility and sterility, 2016 - Elsevier
Objective To compare circulating microRNA (miRNA) profiles between unexplained
recurrent spontaneous abortion (URSA) and normal early pregnancies (NEP) and to …

[HTML][HTML] miR-221-3p regulates hepatocellular carcinoma cell proliferation, migration and invasion via targeting LIFR

W Tan, Z Li, W **a, J Zhu, R Fan - Annals of Hepatology, 2022 - Elsevier
Abstract Introduction and Objectives Hepatocellular carcinoma (HCC) is one of the most
common and fatal cancers in the world. This study aims to investigate the mechanism by …

[PDF][PDF] RETRACTED: Exosomal MicroRNA-221-3p Confers Adriamycin Resistance in Breast Cancer Cells by Targeting PIK3R1

X Pan, X Hong, J Lai, L Cheng, Y Cheng, M Yao… - Frontiers in …, 2020 - frontiersin.org
Drug resistance in breast cancer (BC) cells continues to be a stern obstacle hindering BC
treatment. Adriamycin (ADR) is a frequently employed chemotherapy agent used to treat BC …

High-throughput screening of Sirtuin family of genes in breast cancer

M Igci, ME Kalender, E Borazan, I Bozgeyik… - Gene, 2016 - Elsevier
Mammalian Sirtuins have been shown to perform distinct cellular functions and deregulated
expression of these genes was reported to be involved in the development of various …

Tunneling nanotubes mediated microRNA-155 intercellular transportation promotes bladder cancer cells' invasive and proliferative capacity

JJ Lu, WM Yang, F Li, W Zhu, Z Chen - International journal of …, 2019 - Taylor & Francis
Objective To investigate differential microRNAs' expression in heterogeneous bladder
cancer cells, as well as to investigate the mechanism of changes in invasive and …