Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …

Fibrosis is characterized by the excessive production of collagen and other extracellular
matrix (ECM) components and represents a leading cause of morbidity and mortality …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Like the major theme of a Mozart concerto, the immense and pervasive extracellular matrix
drives each movement and ultimately closes the symphony, embracing a unique role as the …

The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …

Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …

Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic
nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold …