Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

[HTML][HTML] Computational processing of neural recordings from calcium imaging data

C Stringer, M Pachitariu - Current opinion in neurobiology, 2019 - Elsevier
Highlights•There are several promising techniques for processing calcium imaging
data.•Comparing the accuracy of these methods is difficult, due to lack of ground truth.•The …

Prefrontal cortical regulation of REM sleep

J Hong, DE Lozano, KT Beier, S Chung… - Nature …, 2023 - nature.com
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …

[HTML][HTML] Large-scale two-photon calcium imaging in freely moving mice

W Zong, HA Obenhaus, ER Skytøen, H Eneqvist… - Cell, 2022 - cell.com
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

[HTML][HTML] Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity

NL Turner, T Macrina, JA Bae, R Yang, AM Wilson… - Cell, 2022 - cell.com
We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Spontaneous behaviors drive multidimensional, brainwide activity

C Stringer, M Pachitariu, N Steinmetz, CB Reddy… - Science, 2019 - science.org
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

Meta-reinforcement learning via orbitofrontal cortex

R Hattori, NG Hedrick, A Jain, S Chen, H You… - Nature …, 2023 - nature.com
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple
timescales, has been successful in training deep RL models that generalize to new …

Neural dynamics underlying associative learning in the dorsal and ventral hippocampus

JS Biane, MA Ladow, F Stefanini, SP Boddu… - Nature …, 2023 - nature.com
Animals associate cues with outcomes and update these associations as new information is
presented. This requires the hippocampus, yet how hippocampal neurons track changes in …

High-dimensional geometry of population responses in visual cortex

C Stringer, M Pachitariu, N Steinmetz, M Carandini… - Nature, 2019 - nature.com
A neuronal population encodes information most efficiently when its stimulus responses are
high-dimensional and uncorrelated, and most robustly when they are lower-dimensional …

Gut–brain circuits for fat preference

M Li, HE Tan, Z Lu, KS Tsang, AJ Chung, CS Zuker - Nature, 2022 - nature.com
The perception of fat evokes strong appetitive and consummatory responses. Here we show
that fat stimuli can induce behavioural attraction even in the absence of a functional taste …