Making sense of astrocytic calcium signals—from acquisition to interpretation
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
[HTML][HTML] Computational processing of neural recordings from calcium imaging data
Highlights•There are several promising techniques for processing calcium imaging
data.•Comparing the accuracy of these methods is difficult, due to lack of ground truth.•The …
data.•Comparing the accuracy of these methods is difficult, due to lack of ground truth.•The …
Prefrontal cortical regulation of REM sleep
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …
[HTML][HTML] Large-scale two-photon calcium imaging in freely moving mice
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …
[HTML][HTML] Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity
We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …
Spontaneous behaviors drive multidimensional, brainwide activity
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …
Meta-reinforcement learning via orbitofrontal cortex
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple
timescales, has been successful in training deep RL models that generalize to new …
timescales, has been successful in training deep RL models that generalize to new …
Neural dynamics underlying associative learning in the dorsal and ventral hippocampus
Animals associate cues with outcomes and update these associations as new information is
presented. This requires the hippocampus, yet how hippocampal neurons track changes in …
presented. This requires the hippocampus, yet how hippocampal neurons track changes in …
High-dimensional geometry of population responses in visual cortex
A neuronal population encodes information most efficiently when its stimulus responses are
high-dimensional and uncorrelated, and most robustly when they are lower-dimensional …
high-dimensional and uncorrelated, and most robustly when they are lower-dimensional …
Gut–brain circuits for fat preference
The perception of fat evokes strong appetitive and consummatory responses. Here we show
that fat stimuli can induce behavioural attraction even in the absence of a functional taste …
that fat stimuli can induce behavioural attraction even in the absence of a functional taste …