Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …

Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …

Abstract Poly (ADP-ribose) polymerase (PARP) is considered an essential component in
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …

Cancer is a wide collection of diseases and among the numerous pathways involved in
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …

Cancer is a major societal, public health, and economic burden in the 21 st century, with 9.7
million deaths in 2022 (9.96 million in 2020) and 20 million new cancer cases (19.6 million …

Background Epilepsy is a chronic neurological disorder that affects approximately 50–70
million people worldwide. Epilepsy has a significant economic and social burden on patients …

Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …

Background With the recognition that noncancerous cells function as critical regulators of
brain tumor growth, we recently demonstrated that neurons drive low-grade glioma initiation …

In the search for more effective and safer antiepileptic drugs, a series of 5, 6-difluoro-1H-
benzo [d] imidazole derivatives (4a-e) were designed and synthesized. Elemental analysis …