Autonomic manifestations of epilepsy: emerging pathways to sudden death?

RD Thijs, P Ryvlin, R Surges - Nature Reviews Neurology, 2021 - nature.com
Epileptic networks are intimately connected with the autonomic nervous system, as
exemplified by a plethora of ictal (during a seizure) autonomic manifestations, including …

[HTML][HTML] Sleep and epilepsy: a focused review of pathophysiology, clinical syndromes, co-morbidities, and therapy

JL Moore, DZ Carvalho, EK St Louis, C Bazil - Neurotherapeutics, 2021 - Elsevier
A healthy brain requires balancing of waking and slee** states. The normal changes in
waking and slee** states result in neurophysiological conditions that either increase or …

Serotonin and sudden unexpected death in epilepsy

AN Petrucci, KG Joyal, BS Purnell, GF Buchanan - Experimental neurology, 2020 - Elsevier
Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures.
Approximately one-third of epilepsy patients will not achieve seizure freedom with medical …

A unified hypothesis of SUDEP: Seizure‐induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and …

CL Faingold, HJ Feng - Epilepsia, 2023 - Wiley Online Library
Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …

Seizures cause prolonged impairment of ventilation, CO2 chemoreception and thermoregulation

FA Teran, RK Sainju, E Bravo, J Wagnon… - Journal of …, 2023 - Soc Neuroscience
Sudden unexpected death in epilepsy (SUDEP) has been linked to respiratory dysfunction,
but the mechanisms underlying this association remain unclear. Here we found that both …

The translational benefits of sheep as large animal models of human neurological disorders

SJ Murray, NL Mitchell - Frontiers in Veterinary Science, 2022 - frontiersin.org
The past two decades have seen a considerable rise in the use of sheep to model human
neurological disorders. While each animal model has its merits, sheep have many …

Commercially available seizure detection devices: A systematic review

J Shum, D Friedman - Journal of the Neurological Sciences, 2021 - Elsevier
Importance Epilepsy can be associated with significant morbidity and mortality. Seizure
detection devices could be invaluable tools for both people with epilepsy, their caregivers …

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient

P Ryvlin, S Rheims, SD Lhatoo - Current opinion in neurology, 2019 - journals.lww.com
Risks and predictive biomarkers of sudden unexpected death i... : Current Opinion in
Neurology Risks and predictive biomarkers of sudden unexpected death in epilepsy patient …

[HTML][HTML] Failure to breathe persists without air hunger or alarm following amygdala seizures

GIS Harmata, AE Rhone, CK Kovach, S Kumar… - JCI insight, 2023 - ncbi.nlm.nih.gov
Postictal apnea is thought to be a major cause of sudden unexpected death in epilepsy
(SUDEP). However, the mechanisms underlying postictal apnea are unknown. To …

Video-based detection of generalized tonic-clonic seizures using deep learning

Y Yang, RA Sarkis, R El Atrache… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
Timely detection of seizures is crucial to implement optimal interventions, and may help
reduce the risk of sudden unexpected death in epilepsy (SUDEP) in patients with …