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Mass spectrometry-based metabolomics in microbiome investigations
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …
Identification of bioactive metabolites using activity metabolomics
The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
Human metabolome variation along the upper intestinal tract
Most processing of the human diet occurs in the small intestine. Metabolites in the small
intestine originate from host secretions, plus the ingested exposome and microbial …
intestine originate from host secretions, plus the ingested exposome and microbial …
Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra
Metabolomics using nontargeted tandem mass spectrometry can detect thousands of
molecules in a biological sample. However, structural molecule annotation is limited to …
molecules in a biological sample. However, structural molecule annotation is limited to …
[HTML][HTML] Molecular choreography of acute exercise
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune
pathways. Although studies have examined selected changes in these pathways, the system …
pathways. Although studies have examined selected changes in these pathways, the system …
Ion mobility collision cross-section atlas for known and unknown metabolite annotation in untargeted metabolomics
The metabolome includes not just known but also unknown metabolites; however,
metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility …
metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility …
A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels
A new generation of plant-based meat alternatives—formulated to mimic the taste and
nutritional composition of red meat—have attracted considerable consumer interest …
nutritional composition of red meat—have attracted considerable consumer interest …
Challenges, progress and promises of metabolite annotation for LC–MS-based metabolomics
Highlights•Data independent MS/MS acquisition methods improve metabolite
identification.•A step-by-step workflow is needed to assess the accuracy of metabolite …
identification.•A step-by-step workflow is needed to assess the accuracy of metabolite …
High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice
The mammalian gut harbors a complex and dynamic microbial ecosystem: the microbiota.
While emerging studies support that microbiota regulates brain function with a few molecular …
While emerging studies support that microbiota regulates brain function with a few molecular …
Metabolomics study of COVID-19 patients in four different clinical stages
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the coronavirus
strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To …
strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To …