Mechanisms of alternative lengthening of telomeres
In recent years, significant advances have been made in understanding the intricate details
of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a …
of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a …
[HTML][HTML] Integrated genomic and clinicopathologic approach distinguishes pancreatic grade 3 neuroendocrine tumor from neuroendocrine carcinoma and identifies a …
Distinguishing grade 3 pancreatic neuroendocrine tumor (G3 PanNET) from neuroendocrine
carcinoma (PanNEC) is a known diagnostic challenge, and accurate classification is critical …
carcinoma (PanNEC) is a known diagnostic challenge, and accurate classification is critical …
Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management …
Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …
Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 …
Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …
Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification …
X Hong, S Qiao, F Li, W Wang, R Jiang, H Wu, H Chen… - Gut, 2020 - gut.bmj.com
Objective Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-
PanNETs) have distinctive clinical presentations but share similar pathological features …
PanNETs) have distinctive clinical presentations but share similar pathological features …
The identification and validation of two heterogenous subtypes and a risk signature based on ferroptosis in hepatocellular carcinoma
Z Liu, L Wang, L Liu, T Lu, D Jiao, Y Sun… - Frontiers in …, 2021 - frontiersin.org
Background Ferroptosis is essential for tumorigenesis and progression of hepatocellular
carcinoma (HCC). The heterogeneity of ferroptosis and its relationship with tumor …
carcinoma (HCC). The heterogeneity of ferroptosis and its relationship with tumor …
GLIS rearrangement is a genomic hallmark of hyalinizing trabecular tumor of the thyroid gland
MN Nikiforova, AV Nikitski, F Panebianco, C Kaya… - Thyroid, 2019 - liebertpub.com
Background: Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm with a
characteristic trabecular growth pattern and hyalinization. This lesion has been the subject …
characteristic trabecular growth pattern and hyalinization. This lesion has been the subject …
Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies
L Lee, T Ito, RT Jensen - Expert review of anticancer therapy, 2019 - Taylor & Francis
Introduction: Recent advances in diagnostic modalities and therapeutic agents have raised
the importance of prognostic factors in predicting overall survival, as well as predictive …
the importance of prognostic factors in predicting overall survival, as well as predictive …
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine
tumors (PanNETs) with associated clinical and genomic information. We identified three …
tumors (PanNETs) with associated clinical and genomic information. We identified three …