Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Single-molecule localization microscopy

M Lelek, MT Gyparaki, G Beliu, F Schueder… - Nature reviews …, 2021 - nature.com
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …

[HTML][HTML] Glioblastoma hijacks neuronal mechanisms for brain invasion

V Venkataramani, Y Yang, MC Schubert, E Reyhan… - Cell, 2022 - cell.com
Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

Cellpose3: one-click image restoration for improved cellular segmentation

C Stringer, M Pachitariu - Nature Methods, 2025 - nature.com
Generalist methods for cellular segmentation have good out-of-the-box performance on a
variety of image types; however, existing methods struggle for images that are degraded by …

Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes

C Qiao, D Li, Y Liu, S Zhang, K Liu, C Liu, Y Guo… - Nature …, 2023 - nature.com
The goal when imaging bioprocesses with optical microscopy is to acquire the most
spatiotemporal information with the least invasiveness. Deep neural networks have …

Light sheet fluorescence microscopy

EHK Stelzer, F Strobl, BJ Chang, F Preusser… - Nature Reviews …, 2021 - nature.com
Light sheet fluorescence microscopy (LSFM) uses a thin sheet of light to excite only
fluorophores within the focal volume. Light sheet microscopes (LSMs) have a true optical …

Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy

W Zhao, S Zhao, L Li, X Huang, S **ng, Y Zhang… - Nature …, 2022 - nature.com
A main determinant of the spatial resolution of live-cell super-resolution (SR) microscopes is
the maximum photon flux that can be collected. To further increase the effective resolution …

Democratising deep learning for microscopy with ZeroCostDL4Mic

L von Chamier, RF Laine, J Jukkala, C Spahn… - Nature …, 2021 - nature.com
Deep Learning (DL) methods are powerful analytical tools for microscopy and can
outperform conventional image processing pipelines. Despite the enthusiasm and …

Vision Transformers in medical computer vision—A contemplative retrospection

A Parvaiz, MA Khalid, R Zafar, H Ameer, M Ali… - … Applications of Artificial …, 2023 - Elsevier
Abstract Vision Transformers (ViTs), with the magnificent potential to unravel the information
contained within images, have evolved as one of the most contemporary and dominant …

Inference in artificial intelligence with deep optics and photonics

G Wetzstein, A Ozcan, S Gigan, S Fan, D Englund… - Nature, 2020 - nature.com
Artificial intelligence tasks across numerous applications require accelerators for fast and
low-power execution. Optical computing systems may be able to meet these domain-specific …