Design and application of fluorescent probes to detect cellular physical microenvironments

J Ma, R Sun, K **a, Q **a, Y Liu, X Zhang - Chemical Reviews, 2024 - ACS Publications
The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Chemical approaches to optimize the properties of organic fluorophores for imaging and sensing

G Jiang, H Liu, H Liu, G Ke, TB Ren… - Angewandte …, 2024 - Wiley Online Library
Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …

Fluorescent nanoparticles for super-resolution imaging

W Li, GS Kaminski Schierle, B Lei, Y Liu… - Chemical …, 2022 - ACS Publications
Super-resolution imaging techniques that overcome the diffraction limit of light have gained
wide popularity for visualizing cellular structures with nanometric resolution. Following the …

Xanthene, cyanine, oxazine and BODIPY: the four pillars of the fluorophore empire for super-resolution bioimaging

S Samanta, K Lai, F Wu, Y Liu, S Cai, X Yang… - Chemical Society …, 2023 - pubs.rsc.org
In the realm of biological research, the invention of super-resolution microscopy (SRM) has
enabled the visualization of ultrafine sub-cellular structures and their functions in live cells at …

Hybrid small-molecule/protein fluorescent probes

M Minoshima, SI Reja, R Hashimoto, K Iijima… - Chemical …, 2024 - ACS Publications
Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

Super-resolution microscopy for structural cell biology

S Liu, P Hoess, J Ries - Annual Review of Biophysics, 2022 - annualreviews.org
Super-resolution microscopy techniques, and specifically single-molecule localization
microscopy (SMLM), are approaching nanometer resolution inside cells and thus have great …

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

T Liu, T Stephan, P Chen, J Keller-Findeisen… - Proceedings of the …, 2022 - pnas.org
Capturing mitochondria's intricate and dynamic structure poses a daunting challenge for
optical nanoscopy. Different labeling strategies have been demonstrated for live-cell …

Rational design of a highly selective near‐infrared two‐photon fluorogenic probe for imaging orthotopic hepatocellular carcinoma chemotherapy

X Wu, R Wang, S Qi, N Kwon, J Han… - Angewandte Chemie …, 2021 - Wiley Online Library
Selective fluorescence imaging of biomarkers in vivo and in situ for evaluating orthotopic
hepatocellular carcinoma (HCC) chemotherapy remains a great challenge due to current …

Simultaneous two-color visualization of lipid droplets and endoplasmic reticulum and their interplay by single fluorescent probes in lambda mode

L Guo, M Tian, Z Zhang, Q Lu, Z Liu… - Journal of the American …, 2021 - ACS Publications
In living systems, subcellular organelles mutually cooperate and closely contact to form
organelle interaction networks. Thus, the simultaneous and discriminative visualization of …