Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases
A Bhattacharyya, R Chattopadhyay… - Physiological …, 2014 - journals.physiology.org
Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
Thioredoxin reductase inhibition for cancer therapy
R Gencheva, ESJ Arnér - Annual Review of Pharmacology and …, 2022 - annualreviews.org
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
On the medicinal chemistry of gold complexes as anticancer drugs
I Ott - Coordination Chemistry Reviews, 2009 - Elsevier
Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …
and platinum compounds are well established in current cancer chemotherapy. However …
Oxidative stress during HIV infection: mechanisms and consequences
AV Ivanov, VT Valuev-Elliston… - Oxidative medicine …, 2016 - Wiley Online Library
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …
Thioredoxin and related molecules–from biology to health and disease
Thioredoxin and glutaredoxin systems in mammalian cells utilize thiol and selenol groups to
maintain a reducing intracellular redox state acting as antioxidants and reducing agents in …
maintain a reducing intracellular redox state acting as antioxidants and reducing agents in …
Focus on mammalian thioredoxin reductases—important selenoproteins with versatile functions
ESJ Arnér - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
Oxidative stress in malaria parasite-infected erythrocytes: host–parasite interactions
Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …
Biological effects of a nano red elemental selenium
A novel selenium form, nano red elemental selenium (Nano-Se) was prepared by adding
bovine serum albumin to the redox system of selenite and glutathione. Nano-Se has a 7-fold …
bovine serum albumin to the redox system of selenite and glutathione. Nano-Se has a 7-fold …