Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Photoreceptor replacement by transplantation is proposed as a treatment for blindness.
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …

The plasticity of pluripotent stem cells provides new possibilities for studying development,
degeneration, and regeneration. Protocols for the differentiation of retinal organoids from …

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types
self-patterning into a polarized, laminated architecture. In static cultures, organoid …

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Photoreceptor degenerative diseases are a major cause of blindness for which cell
replacement is one of the most encouraging strategies. For stem cell-based therapy using …

The human retina fails to regenerate and cell-based therapies offer options for treatment of
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …

Photoreceptor degeneration due to retinitis pigmentosa (RP) is a primary cause of inherited
retinal blindness. Photoreceptor cell-replacement may hold the potential for repair in a …