Transposable elements in human cancer: causes and consequences of deregulation
Transposable elements (TEs) comprise nearly half of the human genome and play an
essential role in the maintenance of genomic stability, chromosomal architecture, and …
essential role in the maintenance of genomic stability, chromosomal architecture, and …
The epigenetic alterations of endogenous retroelements in aging
M Cardelli - Mechanisms of ageing and development, 2018 - Elsevier
Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …
some of the most abundant repetitive sequences of the human genome, such as Alu and …
CTCF driven TERRA transcription facilitates completion of telomere DNA replication
K Beishline, O Vladimirova, S Tutton, Z Wang… - Nature …, 2017 - nature.com
Telomere repeat DNA forms a nucleo-protein structure that can obstruct chromosomal DNA
replication, especially under conditions of replication stress. Transcription of telomere …
replication, especially under conditions of replication stress. Transcription of telomere …
Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Domestication of transposable elements (TEs) into functional cis-regulatory elements is a
widespread phenomenon. However, the mechanisms behind why some TEs are co-opted …
widespread phenomenon. However, the mechanisms behind why some TEs are co-opted …
CRISPR deletion of a SINE-VNTR-Alu (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the MAPT locus
A Fröhlich, LS Hughes, B Middlehurst, AL Pfaff… - Frontiers in …, 2023 - frontiersin.org
Background SINE-VNTR-Alu (SVA) retrotransposons are hominid-specific elements which
have been shown to play important roles in processes such as chromatin structure …
have been shown to play important roles in processes such as chromatin structure …
A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models
A Hall, B Middlehurst, MAM Cadogan, X Reed… - Scientific reports, 2024 - nature.com
Abstract SINE-VNTR-Alu (SVA) retrotransposons represent mobile regulatory elements that
have the potential to influence the surrounding genome when they insert into a locus …
have the potential to influence the surrounding genome when they insert into a locus …
Cancer testis antigens as immunogenic and oncogenic targets in breast cancer
AM Mahmoud - Immunotherapy, 2018 - Taylor & Francis
Breast cancer cells frequently express tumor-associated antigens that can elicit immune
responses to eradicate cancer. Cancer-testis antigens (CTAs) are a group of tumor …
responses to eradicate cancer. Cancer-testis antigens (CTAs) are a group of tumor …
The role of SINE-VNTR-Alu (SVA) retrotransposons in sha** the human genome
O Gianfrancesco, B Geary, AL Savage… - International journal of …, 2019 - mdpi.com
Retrotransposons can alter the regulation of genes both transcriptionally and post-
transcriptionally, through mechanisms such as binding transcription factors and alternative …
transcriptionally, through mechanisms such as binding transcription factors and alternative …
Integrative prediction of gene expression with chromatin accessibility and conformation data
Background Enhancers play a fundamental role in orchestrating cell state and development.
Although several methods have been developed to identify enhancers, linking them to their …
Although several methods have been developed to identify enhancers, linking them to their …
Roles of cancer/testis antigens (CTAs) in breast cancer
Y Li, J Li, Y Wang, Y Zhang, J Chu, C Sun, Z Fu… - Cancer letters, 2017 - Elsevier
Breast cancer is the most common cancer diagnosed and is the second leading cause of
cancer death among women in the US. For breast cancer, early diagnosis and efficient …
cancer death among women in the US. For breast cancer, early diagnosis and efficient …