Natural tissues and organs exhibit an array of spatial gradients, from the polarized neural
tube during embryonic development to the osteochondral interface present at articulating …

Functionally gradient materials (FGM) have gradual variations in their properties along one
or more dimensions due to local compositional or structural distinctions by design …

Aligned fibrous hydrogels capable of recruiting endogenous neural stem/progenitor cells
(NSPCs) show great promise in spinal cord injury (SCI) repair. However, the hydrogels …

Successful tissue regeneration strategies focus on the use of novel biomaterials, structures,
and a variety of cues to control cell behavior and promote regeneration. Studies discovered …

Radial glia (RG) cells that align in parallel in the embryonic brain are found to be able to
guide the directed migration of neurons in response to brain injury. Therefore, biomaterials …

Traumatic brain injury (TBI) and spinal cord injury (SCI) cause millions of deaths and
permanent or prolonged physical disabilities around the globe every year. It generally …

Highlights•Semaphorins and Plexins are crucial proteins in patterning central nervous
system.•Local and cerebrospinal fluid-derived Semaphorins/Plexins influence …

Traumatic injury in the central nervous system can lead to loss of functional neurons.
Transplantation of neural progenitors is a promising therapeutic strategy. However, infusion …

Microfluidics is an appealing platform for drug screening and discovery. Compared with the
conventional drug screening methods based on Petri dishes and experimental animals …

The loss or failure of an organ/tissue stands as one of the healthcare system's most
prevalent, devastating, and costly challenges. Strategies for neural tissue repair and …