The ASK1-signalosome→ p38 MAPK and SAPK/JNK signaling networks promote
senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Quercetin is an important flavonoid that is ubiquitously present in the diet in a variety of fruits
and vegetables. It has been traditionally viewed as a potent antioxidant and anti …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. Previous
studies found that the expression of triggering receptor expressed on myeloid cells 2 …

Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …

Background Maintaining skeletal muscle mitochondrial content and function is important for
sustained health throughout the lifespan. Exercise stimulates important key stress signals …

Over the past 2 to 3 decades, several phenomena have been identified that provide
powerful protection against myocardial infarction and other sequelae of …

Rationale: Atherosclerosis plaque rupture (PR) is the pathological basis and chief culprit of
most acute cardiovascular events and death. Given the complex and important role of …