Water is essential for life in many ways, and without it biomolecules might no longer truly be
biomolecules. In particular, water is important to the structure, stability, dynamics, and …

Infection by a human papillomavirus (HPV) may result in a variety of clinical conditions
ranging from benign warts to invasive cancer depending on the viral type. The HPV E2 …

Papillomavirus E2 protein is required for the replication and maintenance of viral genomes
and transcriptional regulation of viral genes. E2 functions through sequence-specific binding …

Background In an effort to identify the evolutionary changes relevant to E2 function, within
and between papillomavirus genera, we evaluated the E2 binding sites (E2BS) s inside the …

Mucosal human papillomaviruses (HPVs) are etiological agents of oral, anal and genital
cancer. Properties of high-and low-risk HPV types cannot be reduced to discrete molecular …

We describe the formation of protein–DNA contacts in the two-state route for DNA sequence
recognition by a transcriptional regulator. Surprisingly, direct sequence readout establishes …

When proteins bind to their DNA target sites, ordered water molecules are often present at
the protein–DNA interface bridging protein and DNA through hydrogen bonds. What is the …

We have determined the binding strengths between nucleotides of adenine, thymine,
guanine and cytosine in homogeneous single stranded DNAs and homo‐octapeptides …

The E2 proteins are transcription/replication factors from papillomaviruses. Human
papillomaviruses (HPVs) can be broadly divided in two groups; low-risk HPV subtypes …

The DNA binding domain of papillomavirus E2 proteins is at the center of the regulation of
gene transcription and replication of the virus. Its unique fold consists of a β‐barrel domain …