Transposable elements give rise to interspersed repeats, sequences that comprise most of
our genomes. These mobile DNAs have been historically underappreciated—both because …

A substantial proportion of the genome of many species is derived from transposable
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …

Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …

BACKGROUND A large portion of intronic and intergenic space in our genome consists of
repeated sequences. One of the most prevalent is the long interspersed element-1 (LINE-1 …

L1 elements represent the only currently active, autonomous retrotransposon in the human
genome, and they make major contributions to human genetic instability. The vast majority of …

Mammalian genomes are replete with interspersed repeats reflecting the activity of
transposable elements. These mobile DNAs are self-propagating, and their continued …

Repetitive DNA in humans is still widely considered to be meaningless, and variations within
this part of the genome are generally considered to be harmless to the carrier. In contrast, for …

The abundance and diversity of the LINE-1 (L1) retrotransposon differ greatly among
vertebrates. Mammalian genomes contain hundreds of thousands L1s that have …

Human endogenous retroviruses (HERVs) comprise a significant portion of the human
genome, making up roughly 8%, a notable comparison to the 2–3% represented by coding …

Abstract Background Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent
dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji …