Precision medicine and drug optimization in adult inflammatory bowel disease patients

S Vieujean, E Louis - Therapeutic Advances in …, 2023 - journals.sagepub.com
Inflammatory bowel diseases (IBD) encompass two main entities including ulcerative colitis
and Crohn's disease. Although having a common global pathophysiological mechanism …

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

RN Dharavath, C Pina-Leblanc, VM Tang… - Frontiers in Neural …, 2023 - frontiersin.org
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the
global disease burden, contributes substantially to societal and economic costs, and leads …

Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention

ND Volkow, C Blanco - World Psychiatry, 2023 - Wiley Online Library
Substance use disorders (SUDs) are highly prevalent and exact a large toll on individuals'
health, well‐being, and social functioning. Long‐lasting changes in brain networks involved …

Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study

BA Pagni, PD Petridis, SK Podrebarac, J Grinband… - Scientific reports, 2024 - nature.com
This pilot study investigated psilocybin-induced changes in neural reactivity to alcohol and
emotional cues in patients with alcohol use disorder (AUD). Participants were recruited from …

Microbiome alterations in alcohol use disorder and alcoholic liver disease

K Litwinowicz, A Gamian - International Journal of Molecular Sciences, 2023 - mdpi.com
Microbiome alterations are emerging as one of the most important factors that influence the
course of alcohol use disorder (AUD). Recent advances in bioinformatics enable more …

Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review

PV Fischler, M Soyka, E Seifritz… - Frontiers in …, 2022 - frontiersin.org
Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …

Neurosteroids (allopregnanolone) and alcohol use disorder: from mechanisms to potential pharmacotherapy

E Gatta, D Camussi, J Auta, A Guidotti… - Pharmacology & …, 2022 - Elsevier
Abstract Alcohol Use Disorder (AUD) is a multifaceted relapsing disorder that is commonly
comorbid with psychiatric disorders, including anxiety. Alcohol exposure produces a …

Testing pharmacotherapies for alcohol use disorder with cue exposure paradigms: A systematic review and quantitative synthesis of human laboratory trial …

LR Meredith, EM Burnette, SJ Nieto… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Alcohol cue exposure is a widely used experimental paradigm for screening
pharmacotherapies for alcohol use disorder (AUD). Medication‐related reductions in cue …

Drug repurposing of generic drugs: challenges and the potential role for government

KH van der Pol, M Aljofan, O Blin, JH Cornel… - … Health Economics and …, 2023 - Springer
Drug repurposing is the process of identifying a new use for an existing drug or active
substance in an indication outside the scope of the original indication. Drug repurposing has …

A Bayesian meta-analysis of topiramate's effectiveness for individuals with alcohol use disorder

D Fluyau, VK Kailasam… - Journal of …, 2023 - journals.sagepub.com
Background: Topiramate (TPM) has the potential to become one of the most prominent
treatment options for alcohol use disorder (AUD). We investigated the efficacy of TPM for …