Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

Glioblastoma multiforme (GBM) frequently involves amplification and alteration of the
epidermal growth factor receptor (EGFR) gene, resulting in overexpression of varied …

Purpose: The epidermal growth factor receptor (EGFR) is overexpressed in∼ 50% to 60% of
glioblastoma multiforme tumors, and the most common EGFR mutant, EGFRvIII, is …

Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and
lethal primary brain tumor in adults; few treatments are available. Median survival rates …

Glioblastoma multiforme, because of its invasive nature, can be considered a disease of the
entire brain. Despite recent advances in surgery, radiotherapy and chemotherapy, current …

Cell migration through connective tissue, or cell invasion, is a fundamental biomechanical
process during metastasis formation. Cell invasion usually requires cell adhesion to the …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

Neoplastic transformation occurs in all glial cell types of the human nervous system,
producing a wide variety of clinico‐pathological entities and morphological variants …

The ongoing characterization of the genetic and epigenetic alterations in the gliomas has
already improved the classification of these heterogeneous tumors and enabled the …