Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels …

Extracellular vesicles (EVs) are emerging as powerful players in cell‐to‐cell communication
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …

Sleep is an evolutionarily conserved phenomenon, being an important biological necessity
for the learning process and memory consolidation. The brain displays two types of electrical …

Behavioural disruptions are sensitive indicators of alterations to normal animal physiology
and can be used for toxicity assessment. The small vertebrate zebrafish is a leading model …

ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for
ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia …

Behavioural studies provide insights into normal and disrupted biological mechanisms. In
many research areas, a growing spectrum of animal models—particularly small organisms …

Drug metabolism is one of the critical determinants of drug disposition throughout the body.
While traditionally associated with the liver, recent research has unveiled the presence and …

Abstract The concept of “Neurovascular Unit”(NVU) was put forward, so that the research
goal of Central Nervous System (CNS) diseases gradually transitioned from a single neuron …

In the present study, we characterize a novel zebrafish mutant of solute carrier 18A2
(slc18a2), also known as vesicular monoamine transporter 2 (vmat2), that exhibits a …

OBJECTIVE: Parkinson's disease (PD) is one of the neurodegenerative diseases. Galectin-1
(Gal-1) is expressed in the central nervous system. Our study sought to explore the …