Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Enzymes, representing the largest and by far most complex group of proteins, play an
essential role in all processes of life, including metabolism, gene expression, cell division …

Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease …

Background Over the last ten years, there has been explosive development in methods for
measuring gene expression. These methods can identify thousands of genes altered …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …

Publicly available gene expression datasets deposited in the Gene Expression Omnibus
(GEO) are growing at an accelerating rate. Such datasets hold great value for knowledge …

The cellular composition of a tumor greatly influences the growth, spread, immune activity,
drug response, and other aspects of the disease. Tumor cells are usually comprised of a …

Background Assigning every human gene to specific functions, diseases and traits is a
grand challenge in modern genetics. Key to addressing this challenge are computational …

Cell type annotation is a fundamental task in the analysis of single-cell RNA-sequencing
data. In this work, we present CellO, a machine learning-based tool for annotating human …

A key challenge for the diagnosis and treatment of complex human diseases is identifying
their molecular basis. Here, we developed a unified computational framework, URSA HD …