With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Summary RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary
miRNA transcript and releasing a pre-miRNA with a 2 nt 3′ overhang. Dicer recognizes the …

Most organisms have evolved defense mechanisms to protect themselves from viruses and
other pathogens. Arthropods lack the protein-based adaptive immune response found in …

This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …

Toll-like receptors (TLRs) play key roles in activating immune responses during infection.
The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped …

The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70
amino acids adopting an αβββα fold, whose central property is to bind to double-stranded …

RNA interference (RNAi) induced by short interfering RNA (siRNA) allows for discovery
research and large-scale screening,,,,; however, owing to their size and anionic charge …