The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Rapid developments in stem cell research in recent years have provided a solid foundation
for their use in medicine. Over the last few years, hundreds of clinical trials have been …

Intradural spinal tumors are rare tumors of the central nervous system. Due to the eloquence
of the spinal cord and its tracts, the compact architecture of the cord and nerves, and the …

Anamniotes, rodents, and young humans maintain neural stem cells in the ependymal zone
(EZ) around the central canal of the spinal cord, representing a possible endogenous source …

The finding that the adult mammalian brain is still capable of producing neurons has ignited
a new field of research aiming to identify the molecular mechanisms regulating adult …

In the mammalian adult brain, neural stem cells persist in neurogenic niches. The
subependymal zone is the most prolific neurogenic niche in adult rodents, where residing …

Adult neurogenesis has been described in two canonical regions of the adult central
nervous system (CNS) of rodents, the subgranular zone (SGZ) of the hippocampus and the …

It is currently accepted that the human brain has a limited neurogenic capacity and an
impaired regenerative potential. We have previously shown the existence of CD271 …

During neurogenesis, vertebrate and Drosophila progenitors change over time as they
generate a diverse population of neurons and glia. Vertebrate neural progenitors have long …

Any adult who has tried to take up the piano or learn a new language is faced with the
sobering realization that acquiring such skills is more challenging as an adult than as a …