The transmission of extracellular signals to the interior of the cell is a function of plasma
membrane receptors, of which the seven transmembrane receptor family is by far the largest …

Transforming growth factor β (TGF-β) plays an important role in normal development and
homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling …

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …

The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Bacteria use diverse small molecules for extra-and intracellular signaling. They scan small-
molecule mixtures to access information about both their extracellular environment and their …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

Cells operate through protein interaction networks organized in space and time. Here, we
describe an approach to resolve both dimensions simultaneously by using proximity …

This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …